Fig. 5.

In vivo effects of saline and polycation/miR-145 complexes on BAPN-induced TAD model. a Time axis of administration, b percent survival, c general phenotypic pattern captured by digital camera, d incidence of TAD and e diameters of thoracic aortic arch of all the groups, and f representative images of H&E- and elastin-thoracic aortic arches from all the treated mice. (*p < 0.05 and **p < 0.01, see “Statistical analysis” in “Methods”; n ≥ 15 animals; error bars represent standard deviation; source data of b–d are provided as a Source Data file)