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. 2019 Jul 18;10(8):551. doi: 10.1038/s41419-019-1783-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a RA-induced schizencephaly in C57BL/6 mouse embryos at 9.5 and 10.5 day. b Cranial neural tissue of normal and RA-induced mouse NTDs was harvested at E9.5 and E10.5, and analyzed by western blotting. Aliquots of total lysates were immunoblotted to indicate antibody. c Representative images from immunohistochemical staining of FBXO30 and pSmad1/5 in the cranial neural tissue from E10.5. d FBXO30 and pSmad1/5 expression scores are shown as box plots, with the horizontal lines representing the median. Data are mean ± s.d. (n = 3), *p < 0.05, by Student’s t test. e Fbxo30 and BMP target genes Gata2, Id2, and Msx1 mRNA in cranial neural tissue of RA-induced mouse NTDs from E9.5 and E10.5 was measured by RT-qPCR. Data are mean ± s.d. (n = 3)