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. 2019 Jul 12;9:564. doi: 10.3389/fonc.2019.00564

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Copyright © 2019 Di Somma, Iannuzzi, Passaro, Forte, Iannone, Gigantino, Indovina, Botti, Giordano, Formisano, Portella, Malfitano and Pentimalli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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dl922-947 inhibits the growth of MPM xenografts. Mice were subjected to intra-tumoral injections with dl922-947 (4 × 10⁶ pfu) twice per week for a total of 5 weeks. (A) The days of treatment are reported; a significant difference (***p < 0.001) in tumor growth was observed at day 28. (B) Dot plot reporting the xenograft volumes at the final endpoint (32nd day of treatment). Three animals from the control group were sacrificed earlier because tumors were either too big or ulcerated, whereas 3 mice in the treated group showed complete tumor regression.