Table 4. Predictive factors for OS using univariate and multivariate analyses of the cohort (n=90).
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Gender | ||||||
| Female | 1 | - | ||||
| Male | 1.58 | 0.82–3.04 | 0.17 | - | - | - |
| Tumor location | ||||||
| Rectum | 1 | - | ||||
| Colon | 0.58 | 0.11–1.13 | 0.11 | - | - | - |
| Histologic types | ||||||
| MAC | 1 | - | ||||
| SRC | 1.97 | 0.96–4.06 | 0.064 | - | - | - |
| Adjuvant CT | ||||||
| No | 1 | 1 | ||||
| Yes | 0.20 | 0.083–0.50 | 0.001 | 0.96 | 0.29–3.21 | 0.95 |
| Cycles of adjuvant CT | ||||||
| <6 | 1 | 1 | ||||
| ≥6 | 0.36 | 0.17–0.76 | 0.007 | 0.21 | 0.083–0.57 | 0.002 |
| Tumor size, cm | ||||||
| <5 | 1 | - | ||||
| ≥5 | 1.42 | 0.91–2.23 | 0.13 | - | - | - |
| Surgical types | ||||||
| Radical | 1 | 1 | ||||
| Palliative | 3.90 | 2.03–7.52 | <0.001 | 1.67 | 0.43–6.49 | 0.46 |
| T stage | ||||||
| T2 | 1 | |||||
| T3 | 1.55 | 0.20–12.13 | 0.67 | - | - | - |
| T4 | 3.93 | 0.52–29.52 | 0.18 | - | - | - |
| N stage | ||||||
| N0 | 1 | 1 | ||||
| N1 | 2.16 | 0.77–6.08 | 0.144 | - | - | - |
| N2 | 2.89 | 1.07–7.76 | 0.035 | - | - | - |
| Metastasis | ||||||
| No | 1 | 1 | ||||
| Yes | 4.39 | 2.24–8.59 | <0.001 | 1.05 | 0.18–5.95 | 0.95 |
| Stage | ||||||
| I/II | 1 | 1 | ||||
| III/IV | 3.25 | 1.83–5.80 | <0.001 | 1.57 | 0.53–4.69 | 0.42 |
| Preoperative CEA levels, U/ml | ||||||
| <3.7 | 1 | 1 | ||||
| ≥3.7 | 3.77 | 1.91–7.43 | <0.001 | 2.43 | 1.13–5.62 | 0.024 |
| Lymphovascular invasion | ||||||
| Negative | 1 | 1 | ||||
| Positive | 3.00 | 1.52–5.39 | 0.002 | 1.36 | 0.53–3.47 | 0.52 |
| Perineural invasion | ||||||
| Negative | 1 | 1 | ||||
| Positive | 1.85 | 0.96–3.57 | 0.065 | 1.28 | 0.59–2.79 | 0.53 |