Table 4. Relationships between TNFAIP8L1 and FLT1 polymorphism and cervical cancer risk according to the stratification by age.
SNP | Model | Genotype | ≤43 | >43 | ||
---|---|---|---|---|---|---|
Gene | OR (95% CI) | P-value | OR (95% CI) | P-value | ||
rs9917028 | Allele | G | 1 | 1 | ||
TNFAIP8L1 | A | 0.75 (0.56–1.02) | 0.064 | 0.84 (0.64–1.12) | 0.238 | |
Genotype | GG | 1 | 1 | |||
GA | 0.94 (0.61–1.43) | 0.766 | 0.75 (0.50–1.15) | 0.187 | ||
AA | 0.45 (0.22–0.91) | 0.026 | 0.80 (0.46–1.40) | 0.434 | ||
Dominant | GG | 1 | 1 | |||
GA-AA | 0.81 (0.54–1.21) | 0.305 | 0.77 (0.52–1.13) | 0.180 | ||
Recessive | GG-GA | 1 | 1 | |||
AA | 0.47 (0.24–0.91) | 0.025 | 0.92 (0.55–1.55) | 0.757 | ||
Additive | — | 0.75 (0.56–1.02) | 0.065 | 0.86 (0.66–1.13) | 0.281 | |
rs10426502 | Allele | G | 1 | 1 | ||
TNFAIP8L1 | A | 0.62 (0.33–1.19) | 0.149 | 0.44 (0.22–0.88) | 0.017 | |
Genotype | GG | 1 | 1 | |||
GA | 0.53 (0.26–1.07) | 0.077 | — | — | ||
AA | — | 0.999 | — | — | ||
Dominant | GG | 1 | 1 | |||
GA-AA | 0.57 (0.29–1.14) | 0.112 | 0.42 (0.21–0.86) | 0.017 | ||
Recessive | GG-GA | 1 | 1 | |||
AA | — | 0.999 | — | — | ||
Additive | — | 0.63 (0.33–1.22) | 0.173 | 0.42 (0.21–0.86) | 0.017 | |
rs1060555 | Allele | C | 1 | 1 | ||
TNFAIP8L1 | G | 0.86 (0.62–1.19) | 0.355 | 0.72 (0.53–0.97) | 0.033 | |
Genotype | CC | 1 | 1 | |||
CG | 0.94 (0.62–1.42) | 0.760 | 0.54 (0.36–0.82) | 0.003 | ||
GG | 0.59 (0.22–1.60) | 0.303 | 0.79 (0.38–1.64) | 0.527 | ||
Dominant | CC | 1 | 1 | |||
CG-GG | 0.89 (0.60–1.34) | 0.583 | 0.58 (0.39–0.85) | 0.005 | ||
Recessive | CC-CG | 1 | 1 | |||
GG | 0.61 (0.23–1.62) | 0.321 | 1.03 (0.50–2.10) | 0.935 | ||
Additive | — | 0.87 (0.61–1.22) | 0.406 | 0.71 (0.52–0.97) | 0.030 | |
rs9513111 | Allele | T | 1 | 1 | ||
FLT1 | C | 1.05 (0.78–1.41) | 0.773 | 0.81 (0.61–1.08) | 0.144 | |
Genotype | TT | 1 | 1 | |||
TC | 0.89 (0.58–1.36) | 0.581 | 1.02 (0.68–1.54) | 0.913 | ||
CC | 1.38 (0.69–2.76) | 0.359 | 0.55 (0.29–1.04) | 0.067 | ||
Dominant | TT | 1 | 1 | |||
TC-CC | 0.96 (0.64–1.44) | 0.852 | 0.89 (0.61–1.31) | 0.561 | ||
Recessive | TT-TC | 1 | 1 | |||
CC | 1.47 (0.76–2.83) | 0.250 | 0.54 (0.29–0.99) | 0.049 | ||
Additive | — | 1.06 (0.78–1.45) | 0.695 | 0.82 (0.62–1.09) | 0.166 |
P-values were calculated with wald-test. P<0.05 indicates statistical significance.