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. 2019 Jul 19;39(7):BSR20190267. doi: 10.1042/BSR20190267

Figure 3. Role of JNK in atherosclerosis.

Figure 3

(A) JNK1 promotes apoptosis in endothelium after chronic inflammation and promotes atherosclerosis. (B) Similar to endothelium, JNK1 in bone marrow-derived immune cells (including monocytes) also promotes apoptosis after chronic inflammation which leads to less atherosclerosis in mice. (C) On the other hand, JNK2 knockout mice were protected from atherosclerosis through reduced number of foam cell formation as internalization of scavenger receptor A and lipid accumulation without phosphorylation of receptor are severely decreased.