Table 3. Summary of overall results and subgroup for the association between the microRNAs genes polymorphisms and arthritis risk.
| Gene | Groups | Subgroups | Number | Sample size (n) | Allelic model | Homozygote model | Heterozygous model | Recessive model | Dominant model | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | POR | PORcorr | OR (95% CI) | POR | PORcorr | OR (95% CI) | POR | PORcorr | OR (95% CI) | POR | PORcorr | OR (95% CI) | POR | PORcor | ||||
| miR-146a rs2910164 (G/C) | Diseases | |||||||||||||||||||
| RA | 10 | 2101 | 2638 | 1.026 (0.941, 1.118) | 0.562 | 0.562 | 1.056 (0.874, 1.277) | 0.573 | 1.146 | 1.018 (0.887, 1.168) | 0.803 | 4.015 | 1.043 (0.900, 1.210) | 0.574 | 1.722 | 1.026 (0.900, 1.169) | 0.702 | 2.808 | ||
| Female | 2 | 644 | 828 | 1.050 (0.905, 1.220) | 0.518 | 2.072 | 1.143 (0.846, 1.544) | 0.384 | 1.152 | 1.183 (0.887, 1.578) | 0.253 | 0.253 | 1.006 (0.810, 1.250) | 0.955 | 4.775 | 1.164 (0.889, 1.525) | 0.270 | 0.540 | ||
| Ethnicity | ||||||||||||||||||||
| Caucasian | 7 | 1172 | 1357 | 1.089 (0.898, 1.321) | 0.385 | 0.385 | 1.094 (0.819, 1.461) | 0.543 | 1.629 | 1.024 (0.866, 1.211) | 0.784 | 3.920 | 1.104 (0.842, 1.448) | 0.474 | 0.948 | 1.069 (0.848, 1.349) | 0.572 | 2.288 | ||
| Asian | 3 | 929 | 1281 | 1.013 (0.897, 1.144) | 0.835 | 1.670 | 1.028 (0.800, 1.322) | 0.828 | 0.828 | 1.005 (0.791, 1.278) | 0.965 | 4.825 | 1.018 (0.853, 1.216) | 0.840 | 2.520 | 1.015 (0.809, 1.272) | 0.898 | 3.592 | ||
| Control source | ||||||||||||||||||||
| PB | 8 | 1380 | 1597 | 1.066 (0.907, 1.252) | 0.438 | 0.438 | 1.082 (0.834, 1.403) | 0.553 | 1.106 | 1.032 (0.878, 1.213) | 0.700 | 2.800 | 1.043 (0.836, 1.300) | 0.711 | 3.555 | 1.036 (0.888, 1.207) | 0.655 | 1.965 | ||
| HB | 2 | 721 | 1041 | 1.020 (0.890, 1.169) | 0.772 | 1.544 | 1.027 (0.778, 1.356) | 0.849 | 2.547 | 0.980 (0.753, 1.275) | 0.880 | 3.520 | 1.044 (0.854, 1.276) | 0.673 | 0.673 | 1.001 (0.781, 1.282) | 0.997 | 4.985 | ||
| Quality score | ||||||||||||||||||||
| ≤7 points | 3 | 627 | 726 | 0.886 (0.750, 1.046) | 0.154 | 0.154 | 0.792 (0.536, 1.170) | 0.242 | 0.726 | 0.876 (0.697, 1.101) | 0.257 | 1.028 | 0.845 (0.582, 1.227) | 0.375 | 1.875 | 0.861 (0.692, 1.071) | 0.178 | 0.356 | ||
| >7 points | 7 | 2692 | 3547 | 1.083 (0.979, 1.198) | 0.123 | 0.123 | 1.155 (0.929, 1.435) | 0.195 | 0.585 | 1.108 (0.933, 1.316) | 0.244 | 0.976 | 1.086 (0.923, 1.276) | 0.320 | 1.600 | 1.132 (0.962, 1.332) | 0.137 | 0.274 | ||
| PsA | Mixture | 2 | 145 | 166 | 0.680 (0.478, 0.967) | 0.032 | 0.096 | 0.535 (0.220, 1.300) | 0.167 | 0.668 | 0.567 (0.351, 0.919) | 0.021 | 0.042 | 0.709 (0.302, 1.665) | 0.429 | 2.145 | 0.570 (0.359, 0.905) | 0.017 | 0.017 | |
| JRA | Mixture | 2 | 360 | 747 | 0.974 (0.804, 1.181) | 0.792 | 3.960 | 0.721 (0.332, 1.567) | 0.409 | 1.227 | 1.179 (0.898, 1.547) | 0.236 | 0.236 | 0.675 (0.331, 1.379) | 0.281 | 0.562 | 1.080 (0.838, 1.392) | 0.554 | 2.216 | |
| AS | Asian | 2 | 713 | 722 | 1.307 (0.736, 2.319) | 0.361 | 1.444 | 1.795 (0.592, 5.445) | 0.301 | 0.903 | 1.378 (1.024, 1.854) | 0.034 | 0.034 | 1.280 (0.586, 2.797) | 0.536 | 2.680 | 1.081 (0.924, 1.265) | 0.192 | 0.384 | |
| miR-499 rs3746444 (T/C) | Diseases | |||||||||||||||||||
| RA | 7 | 1581 | 2169 | 0.791 (0.651, 0.962) | 0.019 | 0.038 | 0.585 (0.386, 0.885) | 0.011 | 0.011 | 0.796 (0.626, 1.013) | 0.064 | 0.320 | 0.662 (0.444, 0.987) | 0.043 | 0.172 | 0.771 (0.603, 0.987) | 0.039 | 0.117 | ||
| Female | 2 | 425 | 485 | 0.747 (0.459, 1.216) | 0.241 | 0.723 | 0.541 (0.260, 1.126) | 0.100 | 0.100 | 0.742 (0.348, 1.582) | 0.440 | 2.200 | 0.624 (0.302, 1.289) | 0.203 | 0.406 | 0.718 (0.358, 1.443) | 0.352 | 1.408 | ||
| Ethnicity | ||||||||||||||||||||
| Caucasian | 4 | 781 | 887 | 0.656 (0.541, 0.795) | 0.000 | <0.01 | 0.418 (0.242, 0.722) | 0.002 | 0.008 | 0.645 (0.508, 0.820) | 0.000 | <0.01 | 0.532 (0.319, 0.885) | 0.015 | 0.075 | 0.618 (0.490, 0.780) | 0.000 | <0.01 | ||
| Asian | 3 | 800 | 1282 | 0.962 (0.799, 1.159) | 0.686 | 2.058 | 0.973 (0.497, 1.904) | 0.935 | 3.740 | 0.956 (0.773, 1.182) | 0.677 | 1.354 | 0.974 (0.498, 1.902) | 0.938 | 4.690 | 0.956 (0.778, 1.175) | 0.670 | 0.670 | ||
| Control source | ||||||||||||||||||||
| PB | 6 | 1375 | 1703 | 0.747 (0.646, 0.863) | 0.000 | <0.01 | 0.514 (0.329, 0.803) | 0.003 | 0.012 | 0.750 (0.631, 0.892) | 0.001 | 0.003 | 0.601 (0.329, 0.921) | 0.019 | 0.095 | 0.730 (0.617, 0.864) | 0.000 | <0.01 | ||
| HB | 1 | 206 | 466 | 1.174 (0.828, 1.664) | 0.369 | 0.369 | 1.532 (0.416, 5.642) | 0.521 | 2.084 | 1.149 (0.773, 1.708) | 0.493 | 1.479 | 1.484 (0.404, 5.449) | 0.552 | 2.760 | 1.173 (0.798, 1.726) | 0.417 | 0.834 | ||
| Quality score | ||||||||||||||||||||
| ≤7 points | 1 | 412 | 486 | 0.823 (0.572, 1.184) | 0.294 | 0.882 | 0.276 (0.029, 2.666) | 0.266 | 0.266 | 0.872 (0.591, 1.286) | 0.490 | 2.450 | 0.281 (0.029, 2.713) | 0.273 | 0.546 | 0.842 (0.574, 1.235) | 0.379 | 1.516 | ||
| >7 points | 6 | 1169 | 1683 | 0.784 (0.622, 0.988) | 0.039 | 0.078 | 0.603 (0.395, 0.921) | 0.019 | 0.019 | 0.779 (0.582, 1.043) | 0.094 | 0.470 | 0.684 (0.455, 1.029) | 0.068 | 0.272 | 0.754 (0.560, 1.015) | 0.063 | 0.189 | ||
| AS | Asian | 1 | 102 | 105 | 1.299 (0.733, 2.301) | 0.370 | 1.110 | 0.356 (0.014, 8.869) | 0.529 | 2.645 | 1.504 (0.800, 2.829) | 0.205 | 0.205 | 0.321 (0.013, 7.964) | 0.488 | 1.952 | 1.439 (0.770, 2.690) | 0.254 | 0.508 | |
As the ‘Statistical analysis’ section described, Pcorr value less than 0.05 was considered statistically significant. Abbreviations: miR-146a rs2910164 (G/C), Allelic model (G vs. C); Homozygote model, (GG vs. CC); Heterozygous model, (GG vs. GC); Recessive model, (GC+GG vs. CC); Dominant model, (GG vs. CC+GC); miR-499 rs3746444 (T/C), Allelic model (T vs. C); Homozygote model: (TT vs. CC); Heterozygous model, (TT vs. TC); Recessive model, (TT+TC vs. CC); Dominant model, (TT vs. TC+CC).