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Plasma equilibrium concentrations of select angiotensin peptides (APs) before and after incubation with 5 μg/mL recombinant human ACE2 (rhACE2) from 6 dogs with stage B2 (top panel) and 7 dogs with stage C (bottom panel) degenerative mitral valve disease. The sizes of the circles are proportional to the median equilibrium concentration (pg/mL) of each AP. See text for description of the modified clinical staging system. *P < .05 versus baseline
