Table 3.

Median and interquartile value of plasma equilibrium concentrations of angiotensin peptides and surrogate measures of plasma renin activity (PRA‐surrogate) and angiotensin‐converting enzyme (ACE‐surrogate) activity in healthy dogs and dogs with heart disease. See text for description of the modified clinical staging system

	Healthy (n = 8)	Stage B1 (n = 8)	Stage B2 (n = 9)	Stage C (n = 9)	P
AT1(1‐10)	77.4	462.9	193.6	3372.9	<.0001
pg/mL	53.8‐95.1	125.3‐662.6	159.6‐274.2	2132.0‐4060.0	H versus C, P < .0001
					B2 versus C, P = .004
AT2(1‐8)	39.9	135.7	75.9	56.2	.10
pg/mL	26.7‐47.7	53.6‐298.0	60.9‐92.9	32.2‐319.2
Ang1‐9	1.8	1.8	1.8	10.3	<.0001
pg/mL	1.8‐1.8	1.8‐1.8	1.8‐1.8	5.9‐27.0	H versus C, P = .0002
					B1 versus C, P = .0002
					B2 versus C, P < .0001
Ang1‐7	11.4	78.3	41.0	486.7	<.0001
pg/mL	7.1‐25.3	19.2‐131.0	27.4‐45.1	214.2‐1168.0	H versus C, P < .0001
					B2 versus C, P = .01
Ang1‐5	7.0	46.4	21.2	25.7	.07
pg/mL	4.1‐10.7	18.3‐78.2	13.5‐26.5	4.6‐152.2
Ang2‐10	8.3	48.6	20.0	502.9	<.0001
pg/mL	5.6‐10.9	16.3‐82.2	13.3‐36.5	354.1‐830.8	H versus C, P < .0001
					B1 versus C, P = .05
					B2 versus C, P = .004
AT3(2‐8)	1.3	10.0	5.9	6.6	.18
pg/mL	1.3‐1.3	3.3‐20.3	1.3‐10.0	1.3‐44.4
AT4(3‐8)	3.6	18.3	6.7	15.7	.19
pg/mL	2.9‐6.6	6.6‐2627.7	4.4‐11.1	1.1‐50.7
Ang2‐7	1.0	4.7	2.4	40.5	<.0001
pg/mL	1.0‐1.0	1.7‐6.5	1.0‐4.5	21.7‐85.8	H versus C, P < .0001
					B2 versus C, P = .007
Ang3‐7	0.5	4.3	0.5	42.5	<.0001
pg/mL	0.5‐0.5	0.5‐8.8	0.5‐3.5	19.0‐93.6	H versus C, P = .0002
					B2 versus C, P = .001
PRA‐surrogate	121.6	658.1	277.1	3401.4	<.0001
pg/mL	80.8‐135.3	178.9‐891.0	206.5‐359.5	2211.0‐4284.0	H versus C, P < .0001
					B2 versus C, P = .006
ACE‐surrogate	0.479	0.499	0.389	0.024	.0001
	0.468‐0.660	0.291‐0.540	0.311‐0.485	0.014‐0.094	H versus C, P = .0002
					B1 versus C, P = .003
					B2 versus C, P = .02