Table 4.
Results of the generalized linear model analysis for association between covariables and log transformed quantitative copper levels or rubeanic acid staining scores in Dobermann livers
| Dutch cohort | American cohort | Combined cohort | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rubeanic acid staining score | Quantitative copper | Quantitative copper | Quantitative copper | |||||||||||||
| (n = 122 dogs) | (n = 91 dogs) | (n = 78 dogs) | (n = 169 dogs) | |||||||||||||
| Covariables | Effect estimate | SE | R 2 | P value | Effect estimate | SE | R 2 | P value | Effect estimate | SE | R 2 | P value | Effect estimate | SE | R 2 | P value |
| ATP7B:c:4358G>A | .35 | .13 | .05 | .01* | .16 | .1 | .04 | .08 | .36 | .12 | .08 | .005** | .26 | .075 | .0007 | .0004*** |
| ATP7A:c.980C>T | NA | NA | NA | NA | NA | NA | NA | NA | .24 | .22 | .04 | .27 | NA | NA | NA | NA |
| Sex (female = 0, male = 1) | −.21 | .19 | .002 | .27 | −.32 | .14 | .02 | .02* | −.11 | .17 | .001 | .51 | −.18 | .11 | .003 | .07 |
| Age (y) | .07 | .05 | .02 | .12 | .14 | .04 | .13 | .001** | .03 | .03 | .002 | .31 | .049 | .023 | .12 | .03* |
| Country (United States) | 1.14 | .11 | .4 | <2e‐16*** | ||||||||||||
Notes: NA indicated ATP7A:c.980C>T not being included in the calculation because of insufficient number of samples; R 2 values were calculated in a univariate model with corresponding independent variable; asterisks indicated the levels of significance.