Figure 1.

Flowchart of the study design. Healthy research dogs (n = 24) were evaluated and, after enrollment (n = 22), randomized to receive enrofloxacin (10 mg/kg PO q24h) and metronidazole (12.5 mg/kg PO q12h), followed 1 hour later by either a placebo or probiotic/synbiotic combination PO, in a blinded controlled crossover trial