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. 2019 Jul 10;26:101273. doi: 10.1016/j.redox.2019.101273

Fig. 14.

Fig. 14

CYR5099 ameliorates Freund's adjuvant (CFA)-induced paw injury in C57BL/6 mice. Mice were injected with CYR5099 (10 and 25 mg/kg body weight, intraperitoneally) or an equal volume of 0.9% saline for 1 h before injecting CFA (1.5 mg/kg body weight) into the intraplantar space in the hind paw. After CFA injection for 4 h, animals were administered L-012 (25 mg/kg body weight, intraperitoneally). (A) Representative chemiluminescent photos of paw edema are shown using a Xenogen IVIS 100 imaging system. (B) ROS generation from (A). (C) Peak ROS production was shown at 5 min after L-012 injection. (D) Paw thickness was measured with a digital Vernier caliper at the indicated times after CFA injection. (E) Paw edema was determined at 240 min after induction. (F) Representative staining photos of H&E, Ly6G, and MPO are shown. Bar = 50 μm. All data are expressed as the mean ± S.E.M (n = 6). *p < 0.5; **p < 0.01 compared with the CFA alone.