Fig. 9.

CYR5099 is proposed to selectively bind to gp91^phoxin vitro. The crystal in-situ structures of (A) FAD-targeted gp91^phox, (B) GTP-targeted p67^phox, and (C) PI3P-targeted p40^phox were adopted from PDB 5O0X, 1E96, and 1H6H, respectively (crystal pose; green color). The calculated in-situ structures of (A) FAD- and CYR5099-targeted gp91^phox, (B) GTP- and CYR5099-targeted p67^phox, and (C) PI3P- and CYR5099-targeted p40^phox (calculated pose; yellow and pink color, respectively). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)