Skip to main content
. 2019 Jun 27;17:288–301. doi: 10.1016/j.isci.2019.06.031

Figure 5.

Figure 5

Working Model Based on Current Knowledge

Cooperative DNA and sex-based RNA methylation in the heart. In this study, we identify the pri-miR-208b promoter hybrid region and sex-based methylation site (CG18) of Mhrt lncRNA. We postulate that the methylation reader MeCP2 and the co-repressor protein complex interact with the pri-miR-208b promoter because the Mhrt lncRNA is unmethylated at CG18 in the male heart. Methylation at position CG18 of Mhrt lncRNA is observed with enriched MeCP2 interaction in the female heart allowing pri-miR-208b transcription. Mhrt lncRNA is also linked with the SWI/SNF-binding determinant Brg1 (Han et al., 2014).