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. 2019 Jul 12;10:494. doi: 10.3389/fpsyt.2019.00494

Figure 1.

Figure 1

The classic “bottom–up” model in imaging genetics. Genetic variations acclimate their influences on the brain. The brain alterations further develop into behavioral phenotype changes, which can be clinically observed as symptoms and cognitive impairments. This observed clinical profile established the base of current phenomenological diagnostic system of psychiatric disorders.