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. 2019 Jul 12;10:1521. doi: 10.3389/fimmu.2019.01521

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Copyright © 2019 Kumar and Sehrawat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A proposed model to elucidate the role of glucocorticoids during differentiation of CD8⁺ T cells. Naïve CD8⁺ T cells upon their activation downregulate the nr3c1 receptor. However as the effector cells further differentiate to become memory cells, nr3c1 receptor is up regulated. Naïve and memory cells owing to their enhanced expression for glucocorticoids undergo dexamethasone induced apoptosis while the effector cells only have limited pool of nr3c1 available for ligating to dexamethasone. The receptor ligation induces translocation of ligated nr3c1 to nucleus where the relative abundance of such complexes dictates the cell function and fate by transcriptional regulation.