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. 2019 Jul 12;10:779. doi: 10.3389/fphar.2019.00779

Figure 9.

Figure 9

Effects of AMPK inhibition on STS-induced cardiac protection. (A) Western blots with densitometric analysis of phospho-AMPK (Thr172) and phospho-mTOR (Ser2448). Graphs show the intensity of each band in arbitrary units. (B) Representative pictures of echocardiography, Masson’s trichrome-stained LV micrographs, hematoxylin and eosin-stained LV micrographs, electron micrographs showing autophagic vacuoles, and immunofluorescent micrographs of LC3 in ischemic border zone of heart. Compound C suppressed STS-induced autophagy along with anti-remodeling effects. # P < 0.05 versus sham; *P < 0.05 versus vehicle; & P < 0.05 versus STS. Veh, vehicle; STS, sodium tanshinone IIA sulfonate; CC, compound C.