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. 2019 Jul 12;12:172. doi: 10.3389/fnmol.2019.00172

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Copyright © 2019 Silberbauer, Gryglewski, Berroterán-Infante, Rischka, Vanicek, Pichler, Hienert, Kautzky, Philippe, Godbersen, Vraka, James, Wadsak, Mitterhauser, Hacker, Kasper, Hahn and Lanzenberger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time activity curves (TACs) from [¹¹C]DASB bolus PET scans (upper row) and [¹¹C]DASB bolus plus constant infusion PET/MR scans (bottom row) during placebo (left) and citalopram condition (right) are averaged across 7 subjects each. TACs from striatum, thalamus and the cerebellum are illustrated in red, orange, and blue color, respectively. Double-blind application of the pharmacological challenge was performed 60 min after initiation of [¹¹C]DASB bolus plus constant infusion PET/MR scans. Transient increases in tissue activity during the citalopram scans (bottom right) might be caused by peripheral displacement of the tracer from SERT rich tissues, such as the lungs.