Table 5.
Summary data in studies on circulating IGFBP-1, IGFBP-2, and IGFBP-3 levels in GDM and control pregnancies.
| Study type* | References | Pub year | Country | Specimen | Assay | GA | GDM (ng/ml) | Controls (ng/ml) | GDM vs. control difference (95% CI)b | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Method | Weeks | N | Mean | SD | N | Mean | SD | ||||||
| IGFBP-1 | |||||||||||||
| NCC | O'Leary and Longley (26) | 1994 | Australia | Serum | RIA | 28–35 | 34 | 146 | 105 | 200 | 135 | 199 | 11.00 (−25.88, 47.88) |
| PC | Ramirez et al. (20) | 2014 | USA | Serum | ELISA | 26 | 30 | 44.9 | 18.8 | 42 | 62.2 | 21.2 | –17.28 (–26.57, –7.99) |
| NCC | Liao et al. (30) | 2017 | New Zealand | Serum | ELISA | 20 | 28 | 41.04 | 18.1 | 28 | 67.58 | 32.6 | −26.54 (−40.35, 12.73) |
| CC | Lappas (25) | 2015 | Australia | Plasma | ELISA | Delivery | 44 | 54.4 | 33.8 | 30 | 72.3 | 41.1 | −17.90 (−35.77,−0.03) |
| CC | Lappas (25) | 2015 | Australia | Plasma | ELISA | Delivery | 26 | 56.2 | 39.3 | 36 | 41.1 | 31.8 | 15.10 (−3.23, 33.43) |
| PC | Qiu et al. (28) | 2005 | USA | Plasma | ELISA | 13 | 47 | NA | NA | 757 | NA | NA | Categorical data only |
| Meta-Analysisa | <3 studies | ||||||||||||
| In all the 3 GA periods | |||||||||||||
| IGFBP-2 | |||||||||||||
| CC | Lappas (25) | 2015 | Australia | Plasma | ELISA | Delivery | 44 | 157.8 | 109.4 | 30 | 189.3 | 126.5 | −31.50 (−87.12, 24.12) |
| CC | Lappas (25) | 2015 | Australia | Plasma | ELISA | Delivery | 26 | 150.3 | 131.6 | 36 | 146.4 | 125.4 | 3.90 (−61.19, 68.99) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 10–14 | 107 | 91.61 | 50.44 | 214 | 116.99 | 47.67 | –25.38 (–36.87, –13.89) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 15–26 | 107 | 82.26 | 27.90 | 214 | 103.82 | 41.16 | –21.56 (–29.20, –13.92) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 32–35 | 38 | 78.57 | 29.36 | 45 | 88.92 | 29.36 | −10.35 (−23.03, 2.33) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 36–39 | 51 | 87.44 | 15.53 | 58 | 91.87 | 15.53 | −4.43 (−10.27, 1.41) |
| Meta-Analysisa | <3 studies | ||||||||||||
| In all the 3 GA periods | |||||||||||||
| IGFBP-3 | |||||||||||||
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 10–14 | 107 | 4638.4 | 892.7 | 214 | 4513.9 | 858.2 | 124.5 (−80.0, 329.0) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 15–26 | 107 | 4648.6 | 819.2 | 214 | 4561.2 | 872.1 | 87.4 (−106.9, 281.7) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 32–35 | 38 | 5034.3 | 1596.0 | 45 | 5120.0 | 2089.9 | −85.7 (−879.6, 708.2) |
| NCC | Zhu et al. (27) | 2016 | USA | Plasma | ELISA | 36–39 | 51 | 5085.7 | 1602.9 | 58 | 4965.7 | 1922.5 | 120.0 (−542.1, 782.1) |
| PC | Grissa et al. (21) | 2010 | Tunisia | Serum | ELISA | Delivery | 30 | 1836.5 | 912.9 | 30 | 1302.6 | 912.8 | 533.9 (71.9, 995.9) |
| PC | Hughes et al. (29) | 1995 | Britain | Serum | RIA | 31–40 | 20 | 6612.5 | 1918.7 | 29 | 5546.8 | 1403.5 | 1065.7 (81.8, 2049.6) |
| CC | Lappas (25) | 2015 | Australia | Plasma | ELISA | Delivery | 44 | 3997.4 | 996.3 | 30 | 3693.7 | 1081.2 | 303.7 (−182.5, 789.9) |
| CC | Lappas (25) | 2015 | Australia | Plasma | ELISA | Delivery | 26 | 3959.9 | 1433.3 | 36 | 4029.0 | 1487.4 | −69.1 (−803.7, 665.5) |
| CC | Qian et al. (23) | 2000 | China | Serum | RIA | Delivery | 20 | 5676 | 1628 | 38 | 5746 | 1512 | −70.0 (−930.3, 790.3) |
| NCC | Liao (30) | 2017 | New Zealand | Serum | ELISA | 20 | 28 | 5189.2 | 1783.8 | 28 | 5297.3 | 1270.3 | −108.1 (−919.2, 703.0) |
| Meta-Analysisa | |||||||||||||
| GA | <20 weeks | 1 | Study | <3 studies | |||||||||
| 20–29 | 2 | Study | <3 studies | ||||||||||
| 30+ | 5 | Studies | P = 0.02 | 282.15 (39.78, 524.53) | |||||||||
*
Study type: PC, prospective cohort study; NCC, nested case–control study; CC, case–control study; NA, not available. GA, gestational age; ELISA, enzyme-linked immunosorbent assay; ELCA, enzyme-labeled chemiluminescent assay; RIA, radioimmunoassay.
a
Meta-analysis was conducted in circumstances with ≥3 studies.
b
The differences with 95% CIs excluding the zero are shown in bold.