Table 2.
Patient Demographics
| Variable | Complete Cohort (n=261) | cEEG (n=155) | No cEEG (n=106) | p-value |
|---|---|---|---|---|
| Age | 34.4+/−14.5 | 34.5+/−14.9 | 34.4+/−13.9 | 0.95 |
| Gender (male) | 230 (88.1) | 137 (88.4) | 93 (88.6) | 1.00 |
| Total Glasgow Coma Scale Score | 7 (6–9) | 7 (6–8) | 7 (6–9) | 0.83 |
| Pupils, ≥1 unreactive* | 22 (8.4) | 18 (11.6) | 4 (3.8) | 0.04 |
| Injury severity score | 24 (14–33) | 24 (15–30) | 26 (14–34) | 0.31 |
| IMPACT sum score | 3.1+/−2.6 | 3.0+/−2.6 | 3.3+/−2.7 | 0.51 |
| Marshall CT Class | 0.01 | |||
| I (normal CT) | 30/257 (11.7) | 12 (7.7) | 18/102 (17.6) | |
| II (cisterns present, shift<5mm) | 87/257 (33.9) | 59 (38.1) | 28 (27.5) | |
| III (cisters compressed, shift <5mm) | 45/257 (17.5) | 31 (20.0) | 14 (13.7) | |
| IV (shift>5mm) | 29/257 (11.3) | 14 (9.0) | 15 (14.7) | |
| V (evacuated mass) | 20/257 (7.8) | 10 (6.5) | 10 (9.8) | |
| VI (nonevacuated mass) | 46/257 (17.9) | 29 (18.7) | 17 (16.7) | |
| Presence of traumatic SAH | 164/257 (63.8) | 111 (71.6) | 53 (52) | <0.01 |
| Presence of traumatic IVH | 72/257 (28.0) | 51 (32.9) | 21 (20.6) | 0.05 |
| Study drug (vs. placebo) | 167 (64.0) | 102 (65.8) | 65 (61.3) | 0.54 |
| Antiseizure drug administration | 216 (82.8) | 137 (88.4) | 79 (74.5) | 0.01 |
| Sedation with GABA agonist | 167 (64.0) | 112 (72.3) | 55 (51.9) | <0.01 |
| Outcome (poor, GOS 1–4)** | 114/220 (51.8) | 73/142 (51.4) | 41/78 (52.6) | 0.98 |
*
Only a single patient had bilaterally nonreactive pupils in the group undergoing cEEG.
**
Follow up at 3 months was available for 220/261 (84.3%) of patients