Table 3.

ToxCast p1_v2 chemicals that produced greater than 50% median inhibition (n=3) in the single point screen at 200 μM and were further tested in concentration-response.

		Single Point Screen	Concentration Response
Ranka	Chemical	Median % Inhibition	IC20 (μM)	IC50 (μM)	Hill slope
2	Emamectin benzoate	100	16.68	26.41	−3.06
3	Zoxamide	93	8.18	17.01	−1.95
4	Oxytetracycline	91	7.00	20.24	−1.42
5	Captafol	89	4.78	12.90	−1.47
6	Triflumizole	89	13.28	18.81	−5.01
7	Dicofol	88	35.75	91.95	−1.67
9	Oryzalinb	82	117.64	145.11	−7.97
10	Fluazinam	76	15.26	37.03	−2.27
11	Fenthion	74	3.79	26.38	−0.86
12	Cyazofamid	71	21.09	94.51	−1.09
15	Maneb	68	15.52	50.10	−1.31
16	Azinphos-methyl	66	24.09	85.76	−1.31
17	Diclosulam	59	23.84	161.27	−0.95
18	Fipronil	58	30.78	NA	−1.78
19	Butachlor	58	18.63	40.57	−2.39
20	Chlorothalonil	57	24.52	51.35	−3.23
21	Metolachlor	57	55.73	370.84	−1.79
22	Captan	55	45.26	166.10	−2.77

^aNumber corresponds to median inhibition efficacy rank in single point screen at 200 μM (with the exception of fluazinam, which was plated at 180 μM), shown in Figure 4 and Supplemental Table 1.

^bConcentration-response for TCp1_v2 oryzalin matched internally sourced oryzalin (IC50 = 187.8 μM and Hillslope = −7.97, see Figure 1E).