Table 1.
Effect of withanolide-free Withania somnifera extract on the weight of adrenal glands and spleen in male mice
| Treatment groups | Organ weights (mg) | Relative organ weights (mg/g of body weight) | ||
|---|---|---|---|---|
| Spleen | Adrenal glands | Spleen | Adrenal glands | |
| Stress control | 96.78±1.53 | 19.45±0.85¥ | 3.35±0.12 | 0.75±0.05¥ |
| Nonstress control | 92.80±2.07 | 14.03±0.60* | 3.73±0.18 | 0.51±0.03* |
| REF (TEG: 10 mg/kg) | 94.30±1.74 | 17.07±1.24¥ | 3.43±0.05 | 0.62±0.05 |
| WFWS (3.3 mg/kg) | 96.43±1.50 | 18.58±1.05 | 3.57±0.03 | 0.69±0.04 |
| WFWS (10 mg/kg) | 94.32±1.37 | 16.75±0.74 | 3.44±0.12 | 0.61±0.04 |
| WFWS (33.3 mg/kg) | 93.17±1.23 | 15.27±0.69* | 3.33±0.08 | 0.55±0.03* |
| WFWS (100 mg/kg) | 92.78±1.78 | 14.30±1.13* | 3.33±0.11 | 0.52±0.05* |
Values are mean±SEM (n=6). *Statistically significant difference (one-way ANOVA followed by Student-Newman-Keuls multiple comparison test) relative to stress control group (*P<0.05). ¥Statistically significant difference (one-way ANOVA followed by Student-Newman-Keuls multiple comparison test) relative to nonstress control group (¥P<0.05). W. somnifera: Withania somnifera, SEM: Standard error of mean, ANOVA: Analysis of variance, TEG: Triethylene glycol, WFWS: Withanolides free W. somnifera extract, REF: Reference Control Group