Table 1.
Baseline characteristics
| Characteristics | Elderly (≥ 65 years) | Younger (< 65 years) | Overall | P-value (elderly vs younger) |
|---|---|---|---|---|
| Patients, n (%) | 100 (11.5) | 772 (88.5) | 872 (100) | |
| Type I | 89 (89.0) | 717 (92.9) | 806 (92.4) | |
| Type II | 11 (11.0) | 55 (7.1) | 66 (7.6) | 0.1680 |
| Sex | ||||
| Female, n (%) | 51 (51.0) | 471 (61.0) | 522 (59.9) | 0.0547 |
| Age at enrollment (years) | ||||
| Median (Q1, Q3) | 67.9 (63.8, 70.9) | 36.8 (27.0, 47.3) | 39.5 (27.9, 51.8) | < 0.0001 |
| Age at symptom onset (years) | ||||
| Median (Q1, Q3) | 17.0 (7.0, 25.0) | 12.0 (5.0, 18.0) | 12.0 (5.0, 19.0) | 0.0001 |
| Age at diagnosis (years) | ||||
| Median (Q1, Q3) | 41.0 (30.8, 59.0) | 19.4 (11.4, 30.2) | 21.1 (13.1, 33.8) | < 0.0001 |
| Delay in diagnosis, (years) | ||||
| Median (Q1, Q3) | 23.9 (5.9, 37.2) | 4.8 (0.21, 15.7) | 6.1 (0.3, 17.5) | < 0.0001 |
| Family history of C1-INH-HAE, n, % | ||||
| Yes | 71 (71.0) | 565 (73.2) | 636 (72.9) | |
| No | 11 (11.0) | 100 (13.0) | 111 (12.7) | |
| Unknown | 7 (7.0) | 50 (6.5) | 57 (6.5) | |
| Missing | 11 (11.0) | 57 (7.4) | 68 (7.8) | 0.6051 |
| Attack severity, n (%) | ||||
| Number of attacksa | 581 | 5378 | 5959 | |
| Very mild | 11 (1.9) | 18 (0.3) | 29 (0.5) | |
| Mild | 51 (8.8) | 546 (10.2) | 597 (10.0) | |
| Moderate | 227 (39.1) | 2202 (40.9) | 2429 (40.8) | |
| Severe | 219 (37.7) | 1941 (36.1) | 2160 (36.2) | |
| Very severe | 73 (12.6) | 671 (12.5) | 744 (12.5) | |
| Very mild, mild, moderate vs severe/very severe | 0.4393 | |||
| Attack location, n (%) | ||||
| Number of attacksa | 726 | 6016 | 6742 | |
| Skin | 323 (44.5) | 2702 (44.9) | 3025 (44.9) | 0.958 |
| Abdomen | 369 (50.8) | 3510 (58.3) | 3879 (57.5) | 0.438 |
| Larynx | 38 (5.2) | 293 (4.9) | 331 (4.9) | |
| Other | 70 (9.6) | 216 (3.6) | 286 (4.2) | |
| Use of long-term prophylaxis, n (%) | 2 (3.2) | 8 (2.0) | – | 0.6329 |
| Number of cardiovascular medications, per patient | ||||
| Number of patients | 49 | 66 | 115 | |
| Median (Q1, Q3) | 2.0 (1.0, 3.0) | 1.0 (1.0, 2.0) | 1.0 (1.0, 2.0) | 0.0019 |
C1-INH-HAE hereditary angioedema with C1 inhibitor deficiency, Q quartile
aAttacks with severity/location data included; attacks with “missing” or “unknown” severity/location excluded