Table 2.
Bivariate analysis, very early relapse and early mortality during the first 24 months after diagnosis
| Variable | Very early relapse | Early mortality | ||||
|---|---|---|---|---|---|---|
| # events | RR | IC 95% | # events | RR | IC 95% | |
| Sex | ||||||
| Female (ref.) | 54 | 1 | – | 103 | 1 | – |
| Male | 106 | 1.7 | 1.2–2.4 | 110 | 0.8 | 0.6–1.1 |
| Age | ||||||
| 1–9.9 years (ref.) | 92 | 1 | – | 111 | 1 | – |
| < 1 year | 8 | 2.7 | 1.2–6.4 | 15 | 6.4 | 2.9–13.8 |
| ≥ 10 years | 60 | 1.6 | 1.1–2.3 | 87 | 2.1 | 1.5–2.9 |
| NCI risk classification | ||||||
| Standard (ref.) | 66 | 1 | – | 81 | 1 | – |
| High | 94 | 1.9 | 1.4–2.8 | 132 | 2.5 | 1.8–3.3 |
| Immunophenotype | ||||||
| Pre-B (ref.) | 138 | 1 | – | 173 | 1 | – |
| B mature | 4 | 1.8 | 0.6–5.9 | 3 | 0.9 | 0.3–3.5 |
| Biphenotypic | 5 | 0.8 | 0.3–2.3 | 7 | 1.0 | 0.4–2.3 |
| T Cell | 13 | 0.8 | 0.4–1.5 | 30 | 1.8 | 1.1–2.8 |
| Socioeconomic Status | ||||||
| High (ref.) | 32 | 1 | – | 32 | 1 | – |
| Low-medium | 127 | 0.6 | 0.4–0.9 | 173 | 0.9 | 0.6–1.3 |
| Nutritional status | ||||||
| CDC (percentiles) | ||||||
| Normal (p5–84.9) (ref.) | 79 | 1 | – | 95 | 1 | – |
| Overweight (p85–94.9) | 19 | 1.1 | 0.6–1.9 | 29 | 1.5 | 0.9–2.4 |
| Obesity (≥ p95) | 25 | 1.4 | 0.8–2.2 | 39 | 1.9 | 1.3–3.0 |
| WHO (Z-score) | ||||||
| Normal (−1.9–0.9) (ref.) | 96 | 1 | – | 118 | 1 | – |
| At risk of overweight (1–1.9) | 28 | 0.9 | 0.6–1.5 | 45 | 1.4 | 0.9–2.0 |
| Overweight (2–2.9) | 18 | 1.4 | 0.8–2.4 | 25 | 1.6 | 1.0–2.7 |
| Obesity (≥3) | 8 | 1.3 | 0.6–2.8 | 12 | 1.7 | 0.8–3.3 |
ref reference category, RR relative risk, 95% CI 95% confidence interval