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. 2019 Jun 5;52(7):1761–1770. doi: 10.1021/acs.accounts.9b00109

Figure 3.

Figure 3

Strategies to evaluate the delivery potential of extracellular vesicles. (A) Uptake and intracellular delivery can be tracked by fluorescently labeled vesicles. (B) Functional analysis can be based on the reduction of specific proteins caused by encapsulated siRNA/miRNAs through RNA interference. (C) Alternatively, in a reporter-based system, delivery of Cre-recombinase mRNA results in translation to the functional enzyme causing DNA recombination visualized as a color change of the reporter cell.