FIGURE 1.

General structure of the NPC spanning the nuclear envelope (light blue). Starting from the cytoplasmic side, the cytoplasmic filaments (blue) bind the NPC central structure (green). The central scaffold is characterized by the cytoplasmic ring complex (dark green), inner ring (light green) and nucleoplasmic ring complex (dark green). FG-Nups (red) reside in the central channel where they allow the selective transport of molecules. In terms of the nucleoplasm, a structure called a nuclear basket (gray) anchors the central scaffold. On the right are shown the nucleoporins that make up the nuclear pore complex structures.