Table 2.
Mendelian randomization results for IL‐18, IL‐1ra, IL‐6, and ESR in Alzheimer's disease
| Biomarker | No. SNPs | Beta | 95% CI | P value | |
|---|---|---|---|---|---|
| IL‐18 | |||||
| IVW | 2 | 0.96 | 0.18 | 5.10 | 0.82 |
| IL‐1ra | |||||
| IVW | 3 | 1.02 | 0.64 | 1.49 | 0.85 |
| MR‐Egger | 1.04 | 0.25 | 4.27 | 0.96 | |
| IL‐6 | |||||
| IVW | 3 | 1.00 | 0.96 | 1.03 | 0.78 |
| MR‐Egger | 1.02 | 0.76 | 1.26 | 0.87 | |
| ESR | |||||
| IVW | 4 | 1.37 | 1.01 | 1.85 | 0.05 |
| MR‐Egger | 1.62 | 0.39 | 6.63 | 0.50 | |
CI, confidence interval; ESR, erythrocyte sedimentation rate; IL, interleukin; IVW, inverse variance‐weighted; MR, Mendelian randomization; SNPs, single nucleotide polymorphisms.