Table 2. Cox Proportional Hazards Regression Models and Flexible Parametric Survival Models.
| Covariate | No. | HR (95% CI) | P Value |
|---|---|---|---|
| Model Aa | |||
| Participants | 1248 | NA | NA |
| Depressive relapses | 554 | NA | NA |
| MBCT status (reference: non-MBCT) | NA | 0.69 (0.58-0.82) | <.001 |
| Model Ba | |||
| Participants | 1248 | NA | NA |
| Depressive relapses | 554 | NA | NA |
| MBCT status (reference: non-MBCT) | NA | 0.34 (0.19-0.60) | <.001 |
| MBCT by log(time)b | NA | 1.28 (1.06-1.55) | .01 |
| Model Ca | |||
| Participants | 892 | NA | NA |
| Depressive relapses | 385 | NA | NA |
| MBCT status (reference: active treatments) | NA | 0.78 (0.64-0.96) | .02 |
| Model Da | |||
| Participants | 637 | NA | NA |
| Depressive relapses | 266 | NA | NA |
| MBCT status (reference: antidepressant medication) | NA | 0.77 (0.60-0.98) | .03 |
| Model Ec | |||
| Participants | 1248 | NA | NA |
| Depressive relapses | 554 | NA | NA |
| Between-study SD | 0.0008 | NA | NA |
| MBCT status (reference: non-MBCT) | NA | 0.68 (0.58-0.81) | <.001 |
| Model Fd | |||
| Participants | 1248 | NA | NA |
| Depressive relapses | 554 | NA | NA |
| Between-study SD | 0.0007 | NA | NA |
| MBCT status (reference: non-MBCT) | NA | 0.63 (0.53-0.76) | <.001 |
| Model Ga,e | |||
| Participants | 1022 | NA | NA |
| Depressive relapses | 443 | NA | NA |
| MBCT status (reference: non-MBCT) | NA | 0.74 (0.61-0.90) | .003 |
| Baseline depression score | NA | 1.40 (1.24-1.58) | <.001 |
| Baseline depression score by MBCT status | NA | 0.80 (0.66-0.97) | .02 |
Abbreviations: HR, hazard ratio; MBCT, mindfulness-based cognitive therapy; NA, not applicable.
a
Cox proportional hazards regression model stratified by individual study.
b
Time measured in weeks.
c
Flexible parametric model with 2 df and random treatment effects.
d
Based on model E, with the inclusion of interaction between MBCT status and restricted cubic splines to account for the time-varying effect of MBCT (P = .04).
e
Model adjusted for baseline mindfulness z score, age at onset of depression, and number of past episodes of depression (5 or more/4 or fewer).