Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 18;12:2516865719865282. doi: 10.1177/2516865719865282

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 1. — Model for action of WIN site inhibitors. Left panel: WDR5 is bound to chromatin, downstream of the transcription start site (green arrow), at a conserved group of protein synthesis genes (PSG). WDR5 associates with these genes by engaging a chromatin-resident protein (gray oval) via the WIN site. Association of WDR5 with these genes ensures balanced production of ribosome subunits and other nucleolar and translation factors necessary to support appropriate levels of ribosome production. Right panel: WIN site inhibitors (“i”) displace WDR5 from chromatin, reducing PSG expression. This in turn induces nucleolar stress, activating p53-dependent cellular inhibition.