Table 1.
Relationship between mucosal healing (MH) and histological healing (HH).
| Study | Method | Disease | N patients | Mucosal healing |
Histological healing |
Outcome | ||
|---|---|---|---|---|---|---|---|---|
| Definition | N (%) | Index score | N (%) | |||||
| Fernandez-Blanco et al.31 |
WL | UC | 34 | Mayo score ⩽ 2 | 21 (62%) | Geboes grade ⩽ 3.0 | 9 (26%) | Cohen’s k = 0.293 |
| Bryant et al.39 | WL | UC | 91 | Baron score ⩽1 | 56 (61%) | Truelove and Richards’ Index | 47 (52%) | κ = 0.56 (95% CI 0.36 to 0.77) |
| Iacucci et al.62 | i-scan | UC | 78 | i-scan = 1 | 5 (6.4%) | NYMS = 0 | 18 (78.3%) |
r = 0.65 (95%CI 0.49–0.76) p < 0.0001 |
| Uchiyama et al.67 | LCI | UC | 193 areasa | LCI A | 50 (25.9%) | Matts’ grade = 1 | 47 (24.4%) | p = 0.001b |
| Sasanuma et al.69 | NBI | UC | 52 | BV-BB BV-BH |
41 (78%) | Japanese Ministry of Health, Labour, and Welfare | n/a | p < 0.01 |
| Iacucci et al.72 | OE | UC | 41 UC | i-scan OE mucosal 0–1 vascular 0–1 |
11 (26.8%) 8 (19.5%) |
ECAP RHI |
n/a |
r = 0.70;
p < 0.001 r = 0.61; p < 0.01 |
a
50 patients, calculations are done on the number of areas.
b
LCI index at each Matts’ histopathological grade; ANOVA linear contrast test.
ECAP, extent, chronicity, activity, plus additional findings; LCI, linked colour imaging; NBI, narrow-band imaging; NYMS, New York Mount Sinai system; OE, optical enhancement; RHI, Robarts Histological Index; UC, ulcerative colitis; WL, white light.