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. Author manuscript; available in PMC: 2019 Jul 19.
Published in final edited form as: Adv Biosyst. 2018 Nov 25;3(2):1800252. doi: 10.1002/adbi.201800252

Figure 3. Aligned nanofibrillar collagen films regulate proliferation, inflammatory properties, junctional thickness, and cytoskeletal organization in primary human dermal microvascular ECs despite exposure to spatially varying fluid shear stress.

Figure 3.

A. Randomly-oriented vs. parallel-aligned nanofibrillar collagen films generated by shear-mediated extrusion. B. Aligned scaffolds downregulate expression of ICAM-1, an inflammatory adhesion molecule. C. Aligned scaffolds reduce the fractions of Ki67 expressing cells, indicating reduced EC turnover. D-F. Aligned scaffolds promote CD31 junctional thickness (D), cytoskeletal organization and elongation along the direction of anisotropy (E), as shown by merged images (F). Adapted with permission from [74]. Copyright 2016 American Chemical Society.