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. 2019 Jul 12;9:622. doi: 10.3389/fonc.2019.00622

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Copyright © 2019 Amatu, Schirripa, Tosi, Lonardi, Bencardino, Bonazzina, Palmeri, Patanè, Pizzutilo, Mussolin, Bergamo, Alberti, Intini, Procaccio, Arese, Marsoni, Nichelatti, Zagonel, Siena, Bardelli, Loupakis, Di Nicolantonio, Sartore-Bianchi and Barault.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time to progression of patients enrolled in the study with sample availability and informativeness. Blood draws are represented with filled circles and colored in black when cmDNA/ml was above median, depicted in white when cmDNA/ml was below median; red circles label samples that were not informative (i.e., no positive markers). Patients were sorted by duration of progression free survival. Sixty baseline (among which 57 informative) and 62 under treatment blood draws (among which 56 informative) were available. Fifty seven patients had both types of blood draws available (among which 52 informative in both cases). Two cases were censored for follow-up. Imaging CT-scans are also indicated.