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Total amount of cfDNA (expressed as GE/ml), absolute percentage of mutant (genetic) or methylated (cmDNA) alleles, normalized fraction of methylated cfDNA (cmDNA/ml) in plasma samples drawn at baseline (A) or under regorafenib treatment (B). Patients are stratified according to their PFS. Vertical dotted lines correspond to median value for cmDNA/ml for each time point.
