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. 2019 Jul 12;9:622. doi: 10.3389/fonc.2019.00622

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Copyright © 2019 Amatu, Schirripa, Tosi, Lonardi, Bencardino, Bonazzina, Palmeri, Patanè, Pizzutilo, Mussolin, Bergamo, Alberti, Intini, Procaccio, Arese, Marsoni, Nichelatti, Zagonel, Siena, Bardelli, Loupakis, Di Nicolantonio, Sartore-Bianchi and Barault.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in circulating DNA features between baseline plasma samples (abbreviated as BL) and the second plasma time point collected during regorafenib treatment (labeled as 2nd). For each feature patients were stratified according to their PFS status at 16 weeks. (A) cmDNA, (B) Genetic alterations, (C) total cfDNA amount in GE/ml, (D) cmDNA/ml. p-values compiled using two-tailed u-test.