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. 2019 Jul 12;9:622. doi: 10.3389/fonc.2019.00622

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Copyright © 2019 Amatu, Schirripa, Tosi, Lonardi, Bencardino, Bonazzina, Palmeri, Patanè, Pizzutilo, Mussolin, Bergamo, Alberti, Intini, Procaccio, Arese, Marsoni, Nichelatti, Zagonel, Siena, Bardelli, Loupakis, Di Nicolantonio, Sartore-Bianchi and Barault.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Progression free survival according to cmDNA/ml dynamics (decrease dash line; increase solid line), (B) Overall survival according to baseline cmDNA/ml, (C) Progression free survival according to baseline cmDNA/ml, (D) Progression free survival according to level of cmDNA/ml under treatment (Low ctDNA level dash line; High ctDNA solid line).