Figure 1.

ERG traces from (A) untreated and (B) ticagrelor treated albino ABCA4^−/− mice showing the scotopic response to 0.1 cd·s/m² light 1 day after exposure of mice to 10,000 lux for 6 hours. (C) The magnitude of the a-wave from untreated mice (black circles, n = 20) and mice treated with ticagrelor (red squares, n = 14) 1 day after the light exposure protocol was applied. Symbols represent the mean ± SEM of mouse eyes from batches A–D. P = 0.664, *P = 0.034 and *P = 0.022 for 0.01, 0.1, and 1.0 cd·s/m² respectively. (D) The mean peak b-waves from untreated and ticagrelor-treated mice from same conditions as in panel C; ***P ≤ 0.001 for all. (E) The a-wave measured before and 1,7, and 14 days after application of light protocol (shown as a yellow box) in untreated (black circles, n = 8) and ticagrelor-treated (red squares, n = 8) mice. Results from 1.0 cd·s/m² flash from mouse batch (D) are *P = 0.043 and *P = 0.011 for 1 and 14 days, respectively. (F) The mean b-wave from the same mice as in panel E (n = 8, **P = 0.009, **P = 0.049, and **P = 0.001 for 1, 7, and 14 days, respectively; all comparisons performed with 1-way ANOVA and Tukey's posthoc test, 0.1%–0.15% ticagrelor; see Methods).