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Overview of TDF hydrolysis and proposed drug–drug interaction mechanism between TDF and sofosbuvir. Dashed lines indicate hypothetical mechanism of inhibition of TDF hydrolysis by sofosbuvir. CES, carboxylesterase; SOF, sofosbuvir; TDF, tenofovir disoproxil fumarate; TFV-monoester, tenofovir monoester; TFV, tenofovir; TFV-MP, tenofovir monophosphate; TFV-DP, tenofovir diphosphate.
