Figure 3.

Exposure [AUC_0–24h (mg·h/L), C_{max 0–24h} (mg/L) and C_{min 0–24h} (mg/L)] versus urinary biomarkers KIM-1^a (a, b, c) and OPN^a (d, e, f) relationship by a four-parameter Hill model fit TD: four-parameter Hill model equation: Y = Bottom + (Top–Bottom)/{1 + 10^{[(log_EC50–X)×Hill Slope]}}. Data for clusterin are not shown as they did not show a strong relationship or correlation. ^aUnits for biomarker in ng/mL. Biomarker values were log₂ transformed and exposure values were log₁₀ transformed. EC₅₀, concentration at 50% of total biomarker increase. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.