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Spearman correlation for untransformed PK exposure parameters and urinary biomarkers
| Biomarker | AUC0–24h (rs) | C max 0–24h (rs) | C min 0–24h (rs) |
|---|---|---|---|
| KIM-1 | 0.53 (P < 0.001) | 0.40 (P < 0.001) | 0.49 (P < 0.001) |
| Clusterin | 0.27 (P = 0.06) | 0.18 (P = 0.22) | 0.19 (P = 0.19) |
| OPN | 0.75 (P < 0.001) | 0.68 (P < 0.001) | 0.68 (P < 0.001) |
