Table 1.

VL change from baseline

	Mean change in VL, log10 copies/mL transformed (95% CI)		Non-inferiority test (δ = 0.5)
	A5353, n = 120	SPRING-1 and SINGLE, n = 467
Baseline–week 2	−2.52 (−2.61 to −2.43)	−2.46 (−2.51 to −2.41)	P<0.001
Baseline–week 4	−2.80 (−2.91 to −2.69)	−2.86 (−2.91 to −2.81)	P<0.001
Baseline–week 8	−2.92 (−3.04 to −2.79)	−2.98 (−3.04 to −2.92)	P<0.001
Baseline–week 12	−2.91 (−3.04 to −2.78)	−3.00 (−3.07 to −2.94)	P<0.001
Baseline–week 16	−2.89 (−3.03 to −2.76)	−3.02 (−3.08 to −2.96)	P<0.001
Baseline–week 24	−2.89 (−3.03 to −2.74)	−3.02 (−3.09 to −2.95)	P<0.001