Table 1.

Circulating plasma epoxides and diols in response to exhaustive exercise (n = 6)

Epoxide or diol (μg/mL)	Time point 1 (rest), P1	Time point 2 (HF 150), P2	Time point 3 (exhaustion), P3	Time point 4 (recovery), P4	Greenhouse–Geisser, P value
9,10‐EpOME	23.45 ± 4.65	25.09 ± 7.06	28.37 ± 7.16	23.60 ± 4.87	0.235
12,13‐EpOME	31.90 ± 10.35	35.04 ± 9.16	42.91 ± 12.12	38.97 ± 13.73	Friedman P = 0.029
9,10‐DiHOME	7.16 ± 1.52	7.38 ± 1.58	7.24 ± 1.26	6.51 ± 0.89	0.379
12,13‐DiHOME	11.06 ± 2.61	11.63 ± 2.84	13.64 ± 4.01	13.00 ± 3.20	0.138
5,6‐EET	2.89 ± 0.56	3.29 ± 1.33	3.19 ± 1.22	2.72 ± 0.49	Friedman P = 0.512
8,9‐EET	4.33 ± 0.95	4.88 ± 1.91	4.53 ± 1.75	4.00 ± 0.90	0.348
11,12‐EET	2.58 ± 0.71	2.92 ± 1.04	2.72 ± 0.97	2.38 ± 0.49	0.384
14,15‐EET	3.11 ± 0.94	3.38 ± 1.06	3.11 ± 0.98	3.00 ± 0.76	0.579
5,6‐DHET	3.10 ± 0.81	3.12 ± 0.79	3.46 ± 0.92	3.16 ± 0.91	0.009
8,9‐DHET	1.83 ± 0.48	1.88 ± 0.42	2.04 ± 0.52	1.93 ± 0.58	Friedman P = 0.108
11,12‐DHET	0.55 ± 0.08	0.56 ± 0.05	0.59 ± 0.07	0.53 ± 0.06	0.179
14,15‐DHET	0.42 ± 0.06	0.44 ± 0.04	0.48 ± 0.05	0.45 ± 0.05	0.056
5,6‐EEQ	0.12 ± 0.04	0.12 ± 0.04	0.12 ± 0.03	0.11 ± 0.03	0.766
8,9‐EEQ	0.40 ± 0.09	0.36 ± 0.15	0.35 ± 0.11	0.33 ± 0.09	0.536
11,12‐EEQ	0.21 ± 0.08	0.21 ± 0.07	0.19 ± 0.02	0.20 ± 0.03	0.459
14,15‐EEQ	0.29 ± 0.10	0.29 ± 0.10	0.28 ± 0.08	0.25 ± 0.08	0.621
17,18‐EEQ	0.49 ± 0.16	0.49 ± 0.17	0.44 ± 0.07	0.45 ± 0.09	0.567
5,6‐DiHETE	0.99 ± 0.42	1.05 ± 0.52	1.22 ± 0.43	1.08 ± 0.46	0.019
8,9‐DiHETE	0.52 ± 0.18	0.51 ± 0.17	0.56 ± 0.19	0.52 ± 0.12	Friedman P = 0.163
14,15‐DiHETE	0.26 ± 0.04	0.29 ± 0.08	0.29 ± 0.06	0.23 ± 0.06	0.056
17,18‐DiHETE	1.07 ± 0.13	1.02 ± 0.25	1.29 ± 0.23	1.15 ± 0.23	0.029
7,8‐EDP	1.65 ± 0.30	1.84 ± 0.78	1.78 ± 0.75	1.53 ± 0.34	0.402
10,11‐EDP	1.50 ± 0.26	1.70 ± 0.85	1.57 ± 0.80	1.32 ± 0.36	Friedman P = 0.541
13,14‐EDP	0.92 ± 0.15	1.10 ± 0.40	1.03 ± 0.37	0.87 ± 0.11	Friedman P = 0.668
16,17‐EDP	1.18 ± 0.18	1.29 ± 0.37	1.26 ± 0.35	1.14 ± 0.15	Friedman P = 0.668
19,20‐EDP	1.43 ± 0.38	1.56 ± 0.47	1.61 ± 0.50	1.57 ± 0.64	Friedman P = 0.512
7,8‐DiHDPA	0.41 ± 0.14	0.41 ± 0.14	0.49 ± 0.17	0.45 ± 0.11	0.187
10,11‐DiHDPA	0.07 ± 0.03	0.08 ± 0.03	0.08 ± 0.03	0.07 ± 0.02	0.182
13,14‐DiHDPA	0.05 ± 0.01	0.05 ± 0.01	0.06 ± 0.01	0.05 ± 0.01	0.150
16,17‐DiHDPA	0.23 ± 0.05	0.24 ± 0.06	0.30 ± 0.10	0.26 ± 0.08	Friedman P = 0.056
19,20‐DiHDPA	0.20 ± 0.06	0.20 ± 0.05	0.22 ± 0.07	0.20 ± 0.06	0.249
5‐HETE	19.36 ± 3.59	21.31 ± 6.43	21.57 ± 6.04	19.39 ± 4.46	0.474
8‐HETE	8.88 ± 1.45	10.33 ± 3.80	10.13 ± 3.35	8.84 ± 1.94	0.451
9‐HETE	12.84 ± 2.85	14.97 ± 6.34	14.15 ± 5.36	12.39 ± 2.70	0.485
11‐HETE	19.86 ± 4.24	24.48 ± 10.32	22.67 ± 7.81	18.90 ± 2.94	0.358
12‐HETE	19.38 ± 4.83	20.32 ± 6.12	24.16 ± 8.19	27.09 ± 13.27	0.151
15‐HETE	10.35 ± 2.43	12.15 ± 6.40	11.54 ± 5.67	9.49 ± 2.34	Friedman P = 0.574
20‐HETE	0.22 ± 0.09	0.21 ± 0.09	0.22 ± 0.11	0.20 ± 0.05	0.776
5‐HEPE	2.39 ± 0.93	2.43 ± 1.12	2.30 ± 0.68	2.20 ± 0.81	Friedman P = 0.772
8‐HEPE	0.71 ± 0.29	0.80 ± 0.37	0.76 ± 0.19	0.71 ± 0.33	0.650
9‐HEPE	1.13 ± 0.38	1.23 ± 0.56	1.10 ± 0.37	1.07 ± 0.38	0.683
12‐HEPE	1.40 ± 0.43	1.37 ± 0.52	1.47 ± 0.48	1.58 ± 0.61	0.438
15‐HEPE	0.79 ± 0.29	0.76 ± 0.23	0.75 ± 0.21	0.71 ± 0.20	0.689
18‐HEPE	3.25 ± 0.99	3.51 ± 1.40	3.17 ± 1.08	2.86 ± 0.92	0.393
4‐HDHA	4.99 ± 1.10	6.19 ± 2.92	5.74 ± 2.80	4.68 ± .14	Friedman P = 0.317
7‐HDHA	3.15 ± 0.94	3.43 ± 1.45	3.54 ± 1.33	2.99 ± 0.95	0.478
8‐HDHA	6.17 ± 1.75	6.77 ± 3.18	6.41 ± 2.34	5.55 ± 1.40	0.492
10‐HDHA	3.71 ± 0.92	4.00 ± 1.57	3.93 ± 1.36	3.62 ± 0.66	0.715
11‐HDHA	3.88 ± 1.04	4.23 ± 1.85	3.97 ± 1.38	3.63 ± 0.91	0.577
13‐HDHA	3.23 ± 0.84	3.71 ± 1.82	3.45 ± 1.60	3.02 ± 0.68	0.526
14‐HDHA	10.95 ± 3.13	10.35 ± 2.75	12.05 ± 2.91	14.00 ± 5.70	Friedman P = 0.108
16‐HDHA	2.61 ± 0.63	3.05 ± 1.61	2.82 ± 1.41	2.28 ± 0.55	Friedman 0.073
17‐HDHA	2.97 ± 1.15	4.22 ± 1.30	4.45 ± 1.20	3.69 ± 0.90	0.097
20‐HDHA	8.97 ± 2.34	9.72 ± 4.36	9.68 ± 3.79	8.66 ± 1.83	0.660
21‐HDHA	0.38 ± 0.43	0.45 ± 0.50	0.50 ± 0.60	0.50 ± 0.56	Friedman P = 0.958
13‐HODE	483.37 ± 111.82	521.66 ± 140.02	529.33 ± 160.11	471.45 ± 115.38	Friedman P = 0.668