TABLE 3.
Simulation study with four subgroups. For each g = 0,1,2,3, Δg is difference between the true optimal dose toxicity probability and the true toxicity probability of the dose chosen, P selg is the probability of selecting the optimal dose and N toxg is the mean number of toxicities.
| Seb-TITE | Sep-TITE | TITE | |||||||
|---|---|---|---|---|---|---|---|---|---|
| g | Δg | P selg | N toxg | Δg | P selg | N toxg | Δg | P selg | N toxg |
| Scenario 1 | |||||||||
| 0 | .09 | .46 | 8.4 | .07 | .53 | 7.6 | .23 | .05 | 11.6 |
| 1 | .07 | .60 | 7.9 | .10 | .43 | 7.1 | .04 | .77 | 8.5 |
| 2 | .06 | .55 | 6.6 | .08 | .45 | 6.7 | .09 | .18 | 5.7 |
| 3 | .05 | .53 | 4.9 | .06 | .61 | 5.1 | .09 | 0 | 4.0 |
| Scenario 2 | |||||||||
| 0 | .07 | .80 | 9.5 | .05 | .84 | 8.6 | .38 | < .01 | 14.7 |
| 1 | .06 | .48 | 7.1 | .08 | .34 | 7.0 | .06 | .41 | 14.7 |
| 2 | .06 | .45 | 7.1 | .08 | .37 | 7.1 | .06 | .41 | 6.4 |
| 3 | .07 | .58 | 6.1 | .08 | .55 | 6.6 | .18 | .01 | 4.1 |
| Scenario 3 | |||||||||
| 0 | .07 | .68 | 6.4 | .13 | .57 | 6.6 | .01 | .94 | 8.1 |
| 1 | .06 | .67 | 5.1 | .05 | .73 | 5.3 | .17 | .03 | 4.0 |
| 2 | .06 | .72 | 7.4 | .10 | .55 | 6.9 | .01 | .94 | 8.1 |
| 3 | .05 | .75 | 7.3 | .09 | .56 | 6.8 | .01 | .94 | 8.1 |
| Scenario 4 | |||||||||
| 0 | .05 | .67 | 6.0 | .08 | .53 | 6.4 | .02 | .90 | 7.1 |
| 1 | .06 | .68 | 7.0 | .09 | .52 | 6.6 | .02 | .90 | 7.1 |
| 2 | .05 | .69 | 7.0 | .08 | .53 | 6.7 | .02 | .90 | 7.1 |
| 3 | .05 | .69 | 7.0 | .08 | .54 | 6.5 | .02 | .90 | 7.1 |