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. 2019 Feb 10;8(1):14. doi: 10.3390/antib8010014

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sequence logo of antigen standards spanning predicted the epitope for lineage-specific, head-binding, single domain antibodies. Candidate residues, predicted to have a role in the binding epitope footprint of the Vic2a-6 are numbered, according to the B/HongKong/8/73 [29] within 116–137. Alignment of the B-Victoria (top) pre-lineage split strain (middle) and the B-Yamagata strains (bottom) are shown for the strains used to determine the sdAb-specificity profile (Table 2). Protein sequences used were translated from the DNA sequences: B/Brisbane/60/2008 (gb:ACN29380.1), B/Malaysia/2506/2004 (gb:ACR15732.1), B/Shangdong/9/97 (gb:AAM12546.1), B/Victoria/2/87 (gb:M58428.1) of the B-Victoria lineage; B/Yamagata/16/88 (gb:ABL77255.1), B/Yamanashi/166/98 (gb: CY019531.1), B/Harbin/7/94 (gb:AF060003.1), B/Jiangsu/10/2003 (gb:ACF54202.1), B/Florida/4/2006 (gb:ACF54246.1, B/Massachusetts/02/2012 (gb:KC892118.1), B/Phuket/3037/2013 (GISAID, EPI529345), B/Utah/9/2014 (gb|AMB72003.1) of the B-Yamagata lineage; and the pre-lineage split strain B/HongKong/8/73 (gb: AAA43717.1).