Table 4.
Neutralisation of the influenza B pseudotype viruses.
| Single Domain Antibody | B/Yamagata /16/1988 (Yamagata) IC50 [nM] |
B/Victoria /2/1987 (Victoria) IC50 [nM] |
B/Florida /4/2006 (Yamagata) IC50 [nM] |
B/Brisbane /60/2008 (Victoria) IC50 [nM] |
|---|---|---|---|---|
| Vic2b-3 | 104 | 81 | 246 | 240 |
| Yam2a-10 | - | - | - | - |
| Vic2a-20 | - | 1.1 | - | 112 |
| Vic2a-6 | 315 | 159 | - | 10 |
| YamNGS1#1 | - | - | NT | NT |
| Yam2b-9 | 30.5 | - | NT | NT |
| Vic1b-10 | 0.2 | 15.5 | NT | NT |
| Yam1b-9 | 31.7 | 81.8 | NT | NT |
| Yam2a-1 | 81.8 | 6 | NT | NT |
| Yam2c-16 | NT | NT | NT | NT |
| Vic2c-8 | 202.5 | 228 | NT | NT |
| Yam1b-6 | 26.6 | 12.6 | NT | NT |
| Yam2b-2 | - | 113.5 | NT | NT |
NT—Not Tested; IC50 is the sdAb concentration in nM that gives 50% inhibition; and (-) indicates no neutralisation activity.