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Overall structure and glycosylation. (a) Schematic representation of Immunoglobulin G (IgG). (b) Schematic representation of Immunoglobulin E (IgE). (c) The IgG Cγ2 domain contains complex carbohydrate covalently attached to Asn297 [26]. (d) The IgE Cε3 domain contains high-mannose carbohydrate covalently attached to Asn394 [27]. In panels (c,d), carbohydrate residues are labelled as follows: FUC, fucose; GAL, galactose; MAN, mannose; NAG, N-acetylglucosamine; SIA, sialic acid.
