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Crystal structures of IgE-Fc in complex with anti-IgE Fabs. (a) IgE-Fc in complex with an omalizumab-derived Fab [36]. (b) aεFab/IgE-Fc complex [37]. (c) 8D6 Fab/IgE-Fc complex [38]. In panels (a–c), IgE-Fc chain B is coloured grey while chain A is coloured orange, pink and blue, respectively. The Fab heavy and light chains are coloured in wheat and pale yellow, respectively.
