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Binding of IgE to its receptors is allosterically regulated. (a) sFcεRIα (purple) binds to the Fcε3-4 region when the Cε3 domains adopt an open conformation [44]. (b) sCD23 (orange) binds to the Fcε3-4 region when the Cε3 domains adopt a closed conformation [51]. In panels (a,b), IgE-Fc chains A and B are coloured dark cyan and pale cyan, respectively.
