. 2019 May 9;8(2):32. doi: 10.3390/antib8020032

Table 2.

T-cell receptor (TCR)-like monoclonal antibodies (mAbs) against peptide–major histocompatibility class II (pMHCII).

Antigen	Epitope	MHC	Clone	Indication	Affinity ¹	Selection method	References
2W	EAWGALANWAVDSA	I-A^b	W6	Infection	3.4 nM	Hybridoma	[78]
Eα	ASFEAQGALANIAVDKA	I-A^b	Y-Ae	Self-peptide	0.48 nM	Hybridoma	[79]
LACK	ICFSPSLEHPIVVSGSWD	I-A^d	2C44	Infection	ND	Hybridoma	[80]
insulin	HLVERLYLVCGEEG	I-A^g7	mAb287	Autoimmunity	130 nM	Hybridoma	[81]
p63	RTRPLWVRME	I-A^g7	FS1	Autoimmunity	0.02 nM	Hybridoma	[78]
HEL	NTDGSTDYGILQINSR	I-A^k	B6Ge1	Model antigen	ND	Hybridoma	[82]
HEL	KGTDVQAWIRGCRL	I-A^k	D8H21	Model antigen	ND	Hybridoma	[82]
HEL	DGSTDYGILQINSRW	I-A^k	Aw3.18	Model antigen	12.4 nM	Hybridoma	[83]
MBP	VHFFKNIVTPRTP	I-A^s	B-7-1, B-18-7, C34-72	Autoimmunity	ND	Hybridoma	[84]
MCC	IAYLKQATK	I-E^k	D4,G32,G35	Model antigen	700 nM	Hybridoma	[85]
HLA-A2	SDWRFLRGYHQYA	HLA-DR1	UL-5A1	Self-peptide	ND	Hybridoma	[86]
MBP	ENPVVHFFKNIVTPR	HLA-DR2b	MK16	Autoimmunity	ND	Immunization/phage	[87]
MOG	MEVGWYRPPFSRVVHLYRNGK	HLA-DR2b	2E4, 1F11, 3A3, 3H5, 2C3	Autoimmunity	30–150 nM	Phage	[88]
GAD65	NFFRMVISNPAAT	HLA-DR4.1	G1H12, G3H8, D2	Autoimmunity	64 nM, 104 nM	Phage	[89]
HC gp-39	RSFTLASSETGVG	HLA-DR4.1	12A	Autoimmunity	ND	Hybridoma	[90]
Gluten	QLQPFPQPELPY	HLA-DQ2.5	106, 107 ²	Autoimmunity	70 nM, 100 nM	Phage	[91]

In case of multiple candidate mAbs, the lead candidates are described in the Table. NA; not available. ND; not determined. ¹ Affinity values determined by 1:1 binding using surface plasmon resonance or bio-layer interferometry. ² Docking model of Fv onto pMHC.