Fig. 4.

Participants with A: healthy control, B: diabetes without retinopathy, C: mild to moderate nonproliferative DR (NPDR), D: proliferative DR (PDR). Upper panel of A-D: en face maximum projection of inner retinal angiogram. The inner green line represents the theoretical baseline FAZ (tbFAZ) boundary; the outer green line represents 600 µm distances from the tbFAZ boundary in the transverse direction. The white horizontal line indicates the position of a representative B-scan in the panel below. Lower panel of A-D: cross-sectional B-scan overlaid with angiographic signal (red). The green vertical lines indicate the analytic para-FAZ volume boundary locations in the inner retina. Right panel of A-D: corresponding volumetric para-FAZ OCTA. 3D display using the ImageJ software (http://imageJ.nih.gov/ij/; provided in the public domain by the National Institutes of Health, Bethesda, MD, USA).