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. Author manuscript; available in PMC: 2020 Jul 11.
Published in final edited form as: Mol Cell. 2019 Jun 4;75(1):66–75.e5. doi: 10.1016/j.molcel.2019.05.010

Figure 3. Engineered ribonucleoprotein granules for inhibiting translation within droplet-based protocells.

Figure 3.

(A) Schematic of microfluidic-generated droplets (left) and the inhibition of translation with messenger ribonucleoprotein granules inside the microdroplet protocells (right). Artificial RNA-binding IDPs coacervate mRNA transcripts upon heating and suppress translation, and coacervation is reversed by cooling, leading to resumption of tranlsation.